Table 1 Patient characteristics by case/control status and by lymphoid malignancy subtype.
From: Risk of lymphoid malignancy associated with cancer predisposition genes
Overall | Subtype | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Case (N = 6990) | Control (N = 42,632) | SLL (N = 192) | DLBCL (N = 1146) | FL (N = 1132) | HL (N = 457) | MCL (N = 325) | MM (N = 2138) | MZL (N = 444) | Other B-cell (N = 787) | T-Cell (N = 369) | |
Age | |||||||||||
N | 6986 | 42,456 | 192 | 1146 | 1132 | 457 | 325 | 2134 | 444 | 787 | 369 |
Median | 63 | 63 | 67 | 64 | 61 | 40 | 64 | 63 | 63 | 64 | 61 |
Range | 18.00–94.00 | 18.00–99.00 | 41.00–86.00 | 18.00–94.00 | 19.00–92.00 | 18.00–89.00 | 31.00–94.00 | 25.00–92.00 | 18.00–91.00 | 19.00–94.00 | 18.00–88.00 |
Age category, N (%) | |||||||||||
Missing | 4 | 176 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 |
<60 | 2804 (40.1%) | 17,804 (41.9%) | 49 (25.5%) | 418 (36.5%) | 517 (45.7%) | 337 (73.7%) | 100 (30.8%) | 752 (35.2%) | 179 (40.3%) | 281 (35.7%) | 171 (46.3%) |
60+ | 4182 (59.9%) | 24,652 (58.1%) | 143 (74.5%) | 728 (63.5%) | 615 (54.3%) | 120 (26.3%) | 225 (69.2%) | 1382 (64.8%) | 265 (59.7%) | 506 (64.3%) | 198 (53.7%) |
Sex, N (%) | |||||||||||
Missing | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 |
Female | 2897 (41.5%) | 24,870 (58.3%) | 80 (41.7%) | 483 (42.1%) | 518 (45.8%) | 211 (46.2%) | 77 (23.7%) | 834 (39.1%) | 251 (56.5%) | 299 (38.0%) | 144 (39.0%) |
Male | 4090 (58.5%) | 17,762 (41.7%) | 112 (58.3%) | 663 (57.9%) | 614 (54.2%) | 246 (53.8%) | 248 (76.3%) | 1301 (60.9%) | 193 (43.5%) | 488 (62.0%) | 225 (61.0%) |
Genetic ancestry, N (%) | |||||||||||
Missing | 18 | 168 | 0 | 1 | 5 | 0 | 0 | 5 | 2 | 3 | 2 |
AFR | 98 (1.4%) | 608 (1.4%) | 1 (0.5%) | 4 (0.3%) | 8 (0.7%) | 7 (1.5%) | 2 (0.6%) | 57 (2.7%) | 5 (1.1%) | 6 (0.8%) | 8 (2.2%) |
AMR | 79 (1.1%) | 385 (0.9%) | 0 (0.0%) | 9 (0.8%) | 13 (1.2%) | 6 (1.3%) | 4 (1.2%) | 25 (1.2%) | 12 (2.7%) | 3 (0.4%) | 7 (1.9%) |
EAS | 40 (0.6%) | 318 (0.7%) | 0 (0.0%) | 5 (0.4%) | 6 (0.5%) | 3 (0.7%) | 1 (0.3%) | 12 (0.6%) | 2 (0.5%) | 6 (0.8%) | 5 (1.4%) |
EUR | 6730 (96.5%) | 40,961 (96.5%) | 190 (99.0%) | 1122 (98.0%) | 1096 (97.2%) | 438 (95.8%) | 318 (97.8%) | 2031 (95.2%) | 422 (95.5%) | 768 (98.0%) | 345 (94.0%) |
SAS | 25 (0.4%) | 192 (0.5%) | 1 (0.5%) | 5 (0.4%) | 4 (0.4%) | 3 (0.7%) | 0 (0.0%) | 8 (0.4%) | 1 (0.2%) | 1 (0.1%) | 2 (0.5%) |
Family history of hematologic malignancy, N (%) | |||||||||||
Missing | 2228 | 3402 | 17 | 364 | 284 | 159 | 107 | 831 | 97 | 250 | 119 |
No | 4053 (85.1%) | 35,854 (91.4%) | 153 (87.4%) | 675 (86.3%) | 719 (84.8%) | 266 (89.3%) | 188 (86.2%) | 1093 (83.6%) | 298 (85.9%) | 444 (82.7%) | 217 (86.8%) |
Yes | 709 (14.9%) | 3376 (8.6%) | 22 (12.6%) | 107 (13.7%) | 129 (15.2%) | 32 (10.7%) | 30 (13.8%) | 214 (16.4%) | 49 (14.1%) | 93 (17.3%) | 33 (13.2%) |
