Fig. 1: Genomic landscape and enrichment of genetic variants in rrDLBCL tumors.

A Oncoplot representing recurrent non-silent somatic single variants or insertions/deletions in rrDLBCL tumor samples (n = 204). Predicted functional consequence represented by color (missense, green; truncating, red; in-frame, orange; multi-hit, black). Bar plot (right) represents the sum of samples with a mutation in the respective gene. Genes depicted were filtered for genes with established potential in lymphoma (see Supplemental Table 5). B Oncoplot representing recurrent copy number alterations detected in rrDLBCL tumor samples (n = 132). Predicted event is represented by color (Amplification [Amp], dark red; Gain, light red; Deletion [Del], dark blue; Loss, light blue). Genomic regions depicted were filtered for locations with established potential in lymphoma (see Supplemental Table 6). C Forest plot and enrichment analysis comparing recurrent non-silent somatic single variants or insertions/deletions between rrDLBCL (n = 204) and ndDLBCL (n = 382) tumors. OR > 1 indicates enrichment in rrDLBCL tumors. D Forest plot and enrichment analysis comparing recurrent copy number alterations between rrDLBCL (n = 132) and ndDLBCL (n = 365) tumors. OR > 1 indicates enrichment in rrDLBCL. E Summary visualizing frequency of recurrent non-silent somatic single variants or insertions/deletions and copy number alterations in rrDLBCL and ndDLBCL tumors. Alteration type represented by color (mutation, green; gain, red; loss, blue). For clarity, only SNV and CNV data from genes/regions from C, D are shown. Bubble size represents −Log10(p value). Points above dotted line indicate enrichment in ndDLBCL tumor samples, points below dotted line indicate enrichment in rrDLBCL tumor samples. F LymphGen classification in ndDLBCL (n = 349) and rrDLBCL (n = 131) tumor samples.