Table 1 Patient, disease and transplant characteristics.
Characteristics at transplant | All, n = 50 (%) |
|---|---|
Median age, years (range) | 58.5 (36–67) |
Sex, N(%) | |
Female | 14 (28) |
Males | 36 (72) |
Myelofibrosis, N(%) | |
Primary | 17 (34) |
Secondary to PV/ET | 33 (66) |
ET | 21 |
PV | 12 |
Anemia (Hb <10 g/dl) | 34 (68) |
Severe anemia (Hb < 8 g/dl) | 9 (18) |
Thrombocytopenia | |
Moderate (<100.000/mcl) | 11 (22) |
Severe (<50.000/mcl) | 7 (14) |
Driver.mutations | |
CALR | 14 (28) |
JAK2 | 26 (52) |
MPL | 6 (12) |
Triple negative | 4 (8) |
Bone marrow fibrosis grade | |
1 | 4 (8.2) |
2 | 21 (42.9) |
3 | 24 (49) |
ECOG.PS | |
0 | 18 (36) |
1 | 29 (58) |
2 | 3 (6) |
HCT-CI | |
0 | 12 (24) |
1–2 | 21 (42) |
>2 | 17 (34) |
Splanchnic vein thrombosis | 12 (24) |
Spleen size ≥22 cm | 12 (24) |
Splenectomy | 10 (20) |
Karnofsky ≤70 | 3 (6) |
Trasfusion.dependent.before transplant | 24 (48) |
Ruxolinitib o Fedratinib before transplant | 26 (52) |
Cytogenetic | |
Favorable abnormality | 4 (8.7) |
Normal karyotype | 29 (63) |
Other abnormalities | 7 (15.2) |
Very high-risk abnormalities | 6 (12) |
Time from diagnosis to transplant (years), median (range) | 2.4 (0.2–15.1) |
Donor | |
Sibling | 10 (20) |
Haploidentical | 6 (12) |
Matched unrelated donor | 26 (52) |
Mismatched unrelated donor | 8 (16) |
Source of stem cells | |
Bone marrow | 2 (4) |
Peripheral blood | 48 (96) |
Conditioning regimen | |
Bu + Flu | 12 (24) |
Flu + Mel | 5 (10) |
Flu + Thiotepa | 3 (6) |
Thiotepa + Bu + Flu | 30 (60) |
ATG yes | 37 (74) |
Conditioning intensity | |
RIC | 48 (96) |
MAC | 2 (4) |
