Fig. 7

Contour plot illustrating the joint association of baseline hemoglobin (Hgb) and baseline lactate dehydrogenase (LDH) with median progression-free survival (PFS). Restricted cubic spline models with interaction terms were applied to capture potential non-linear effects. Median PFS (in months) is shown by contour shading, with darker regions representing shorter PFS and lighter regions representing longer PFS.