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Severity, course, and predictors of sleep disruption following hematopoietic cell transplantation: a secondary data analysis from the BMT CTN 0902 trial

Bone Marrow Transplantation volume 53, pages 1038–1043 (2018)Cite this article

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Abstract

Sleep disruption has received little attention in hematopoietic cell transplantation (HCT). The goal of this study was to describe severity, course, and predictors of sleep disruption following HCT. A secondary data analysis was conducted of the Blood and Marrow Transplantation Clinical Trials Network (BMT CTN) 0902 study. Participants completed a modified version of the Pittsburgh Sleep Quality Index prior to transplant and 100 and 180 days posttransplant. Growth mixture models were used to characterize subgroups of patients based on baseline sleep disruption and change over time. A total of 570 patients (mean age 55 years, 42% female) were included in the current analyses. Patients could be grouped into four distinct classes based on sleep disruption: (1) clinically significant sleep disruption at baseline that did not improve over time (20%); (2) clinically significant sleep disruption at baseline that improved over time (22%); (3) sleep disruption that did not reach clinical significance at baseline and did not improve over time (45%); and (4) no sleep disruption at baseline or over time (13%). These data provide a more comprehensive understanding of sleep disruption that can be used to develop interventions to improve sleep in HCT recipients.

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Acknowledgements

We are grateful for the investigators and patients who participated in this trial.

Funding

Support for this study was provided by grant U10HL069294 to the Blood and Marrow Transplant Clinical Trials Network from the National Heart, Lung, and Blood Institute (NHLBI) and the National Cancer Institute (NCI). Additional support was provided by the National Center for Advancing Translational Sciences [National Institutes of Health (NIH)] through grant numbers UL1TR001436 and KL2TR001438. KLS is supported in part by NCI R01 CA215134. The content is solely the responsibility of the authors and does not necessarily represent the official views of the above mentioned parties. This work was performed while PBJ was at the Moffitt Cancer Center and does not represent the views of NIH.

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Authors and Affiliations

  1. Moffitt Cancer Center, Tampa, FL, USA

    Heather S. L. Jim & Steven Sutton

  2. Cleveland Clinic, Cleveland, OH, USA

    Navneet S. Majhail

  3. University of North Carolina, Chapel Hill, NC, USA

    William A. Wood

  4. National Cancer Institute, Bethesda, MD, USA

    Paul B. Jacobsen

  5. University of Florida, Gainesville, FL, USA

    John R. Wingard

  6. The Emmes Corporation, Rockville, MD, USA

    Juan Wu

  7. Medical College of Wisconsin, Milwaukee, WI, USA

    Jennifer M. Knight

  8. Fred Hutchinson Cancer Research Center, Seattle, WA, USA

    Karen L. Syrjala & Stephanie J. Lee

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  1. Heather S. L. Jim
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  4. William A. Wood
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Correspondence to Heather S. L. Jim.

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Conflict of interest

HSLJ is a consultant for RedHill Biopharma. The other authors declare that they have no conflict of interest.

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Jim, H.S.L., Sutton, S., Majhail, N. et al. Severity, course, and predictors of sleep disruption following hematopoietic cell transplantation: a secondary data analysis from the BMT CTN 0902 trial. Bone Marrow Transplant 53, 1038–1043 (2018). https://doi.org/10.1038/s41409-018-0138-0

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