Table 2B Causes of deaths in 114′491 patients with leukemia and HSCT between 1980 and 2015, and cumulative incidences of deaths depending on patient cohort and time period after transplant. Patients after auto-HSCT

From: Death after hematopoietic stem cell transplantation: changes over calendar year time, infections and associated factors

Time period

Cohort

Total at entry

Relapse

Infections

Other causes

Unknown

Total

N D

Cum Inc + CI

N D

Cum Inc + CI

N D

Cum Inc + CI

N D

Cum Inc + CI

N D

Cum Inc + CI

30 days

1

11869

36

0.31§ (0.22–0.42)

198

1.68** (1.46–1.93)

140

1.19*** (1.01–1.40)

13

0.11§ (0.06–0.19)

387

3.29*** (2.98–3.63)

2

6833

23

0.34 (0.23–0.51)

73

1.09 (0.86–1.36)

39

0.58 (0.42–0.79)

8

0.12 (0.06–0.23)

143

2.14 (1.81–2.50)

100 days

1

11336

353

3.14*** (2.83–3.48)

231

2.05*** (1.80–2.32)

209

1.86*** (1.62–2.12)

33

0.29° (0.21–0.41)

826

7.34*** (6.87–7.83)

2

6459

133

2.12 (1.79–2.50)

47

0.74 (0.55–0.98)

44

0.70 (0.51–0.93)

7

0.11 (0.05–0.22)

231

3.67 (3.23–4.16)

1 year

1

10344

2073

20.52** (19.74–21.32)

359

3.54*** (3.20–3.92)

267

2.63* (2.33–2.96)

79

0.78§ (0.62–0.97)

2778

27.48*** (26.61–28.35)

2

5853

974

18.31 (17.28–19.37)

101

1.89 (1.55–2.28)

114

2.12 (1.76–2.54)

39

0.74 (0.53–1.00)

1228

23.06 (21.93–24.21)

5 years

1

7166

1616

23.51*** (22.51–24.52)

199

2.90*** (2.52–3.31)

217

3.18§ (2.79–3.62)

101

1.51§ (1.23–1.82)

2133

31.09*** (29.99–32.20)

2

3773

589

18.04 (16.72–19.40)

52

1.59 (1.20–2.07)

116

3.80 (3.16–4.53)

35

1.14 (0.81–1.57)

792

24.57 (23.07–26.10)

Overall all study patients

1

11869

4349

37.01*** (36.10–37.92)

1011

8.72*** (8.21–9.26)

1018

7.41*** (6.94–7.91)

355

2.07§ (1.82–2.35)

6733

55.22*** (54.28–56.15)

2

6833

1778

32.77 (31.47–34.08)

277

4.75 (4.21–5.33)

356

6.02 (5.38–6.71)

101

1.75 (1.41–2.15)

2512

45.29 (43.88–46.69)

  1. Time period: refers to the time period from day of transplant (see methods for details)
  2. Cohort: refers to the two time periods 1980–2001 (cohort 1) or 2002–2015 (cohort 2)
  3. Total at entry: refers to the number of patients at risk, at entry to the respective time period,
  4. e.g., day 0 for 30 days period, day 30 for 100 days period, day 100 for 1 year period, and 1 year for 5 years period.
  5. N D: number of deaths during the respective time period
  6. Cum Inc + CI: Cumulative Incidence, and 95% confidence intervals. For full details see supplementary Tables 5 and 7.
  7. Statistical significance in Cum Inc between cohort 1 and 2: § = n.s.; ° = < 0.05; * = < 0.01; ** = < 0.001; *** = < 0.0001 (i.e. risk of death from respective cause decreased/increased from cohort 1 to cohort 2)
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