Table 2 Patients characteristics

From: The impact of Host vs. Graft mismatches on rejection of haploidentical bone marrow transplants in thalassemia patients using posttransplant cyclophosphamide

UPN

Age at BMT

Sex

Donor

FU

Pre-BMT Blood Tx

Cell dose (×108/kg)

Day to ANC 500

Day to plt 20,000

DSA

HLA notes

DSA + or HVG +

Latest donor chimerism

Rej

Acute GVHD

CMV activation

Status

Notes

INA16034

4.3

F

Mother

26.4

79

23

17

16

Neg

A compatible

No

100

No

2

Yes

A&TF

 

INA15054

2.2

M

Father

25.0

28

15.38

17

15

Neg

A compatible

No

61

No

0

Yes

A&TF

 

INA15007

3.9

F

Mother

17.2

69

18.5

14

12

Not done

B & DPB1 compatible

No

100

No

1

No

A&TF

 

INA15020

3.4

M

Mother

18.4

57

21.7

24

15

Neg

 

No

99

No

2

No

A&TF

 

INA12018

8.9

M

Mother

13.7

120

15.4

19

20

Neg

DRB1, DQB1 & DPB1 compatible

No

100

No

0

No

A&TF

Possible IFD

INA13107

8

M

Mother

16.2

90

20.5

26

14

Neg

DQB1 GVH vector

No

100

No

0

No

A&TF

MAS

INA12057

9.4

M

Mother

NA

201

16.05

26

35

Neg

DRB1, DQB1 & DPB1 compatible

No

100

No

0

No

TRM

BK virus HC, ICH

INA17022

5.1

F

Mother

13.0

50

13.7

24

18

Neg

 

No

100

No

1

No

A&TF

 

INE16041

5.9

F

Mother

12.2

117

52.9

18

18

Neg

B, C, DRB1 & DQB1 GVH vector

No

97

No

0

No

A&TF

 

INE17035

13.5

M

Mother

NA

147

12.14

20

25

Neg

DRB1, DQB1 & DPB1 compatible

No

97

No

0

No

TRM

Probabble IFD

INA10055

11.5

M

Father

11.2

198

13.28

24

27

Neg

DRB1, DQB1 & DPB1 compatble, A HVG vector

No

100

No

2

No

A&TF

 

INA17041

2

M

Mother

10.3

20

14.12

13

16

Neg

A, C, DRB1, DQB1 & DPB1 compatible

No

100

No

2

No

A&TF

 

INE15024

3

M

Mother

9.5

36

44.4

14

18

Neg

DRB1 compatible, DQB1 GVH vector

No

100

No

0

No

A&TF

 

AFC17001

3.4

M

Mother

8.5

57

18.4

NA

NA

Neg

DPB1 compatible

No

0

d + 30

0

No

A&T

PGF-PP, Probable IFD

INA11012

9.5

F

Mother

7.5

204

16

17

39

Neg

C compatible

No

100

No

0

No

A&TF

2nd BMT after MRD rejection, MAS, SOS

INA13015

10.7

M

Father

6.5

232

16

18

19

Neg

 

No

100

No

2

No

A&TF

 

INA13128

7

M

Father

6.1

144

14.3

20

16

Neg

DRB1 & DQB1 GVH vector

No

98

No

0

No

A&TF

 

INM17025

3.9

M

Mother

5.7

69

23.8

18

19

Neg

B, C, DRB1 & DQB1 compatible, A HVG vector

No

84

No

0

No

A&TF

Responded to DLI for EMC

INA17009

2.1

M

Father

NA

12

16.26

19

18

Neg

A, C, DPB1 GVH vector

No

NA

No

4

No

TRM

Severe GVHD-Sepsis

INA14043

3.5

M

Father

10.9

60

19.13

23

16

Pos

DRB1 & DQB! GVH vector, A HVG vector

Yes

100

No

2

Yes

Dead

Death unrelated to BMT

INA16078

5.8

M

Mother

18.9

115

16.3

NA

NA

Neg

C compatible, DRB1 HVG vector

Yes

0

d + 29

0

No

A&T

PGF-EAR

INE16076

4.2

F

Mother

18.3

76

14.6

21

29

Neg

DRB1 & QB1 compatible, A HVG vector

Yes

100

No

0

Yes

A&TF

 

INA16041

5.5

M

Mother

NA

108

20.16

21

19

Pos

C compatible

Yes

3

d + 43

0

No

TRM

SGF

INC15040

8.3

F

Mother

14.2

175

16

NA

NA

Pos

 

Yes

0

d + 25

0

Yes

A&T

PGF-PP, Provem IFD

INA17120

1.5

M

Mother

14.1

12

18.9

20

36

Pos

A GVH vector

Yes

100

No

1

No

A&TF

 

INE17044

10

F

Father

13.0

170

21.21

35

54

Neg

DRB1 & DPB1 HVG vector

Yes

0

d + 20

0

No

A&T

PGF-PP, SOS

INA17021

7.3

M

Mother

11.8

90

16.21

NA

NA

Neg

A HVG vector

Yes

0

d+25

0

No

A&T

PGF-PP

INA15003

4.6

M

Mother

NA

86

17.4

NA

NA

Neg

A HVG vector

Yes

100

No

3

No

TRM

MAS

  1. FU follow-up, Rej rejection, A&TF alive and thalassemia-free, A&T alive with thalassemia, TRM transplant-related mortality, MAS macrophage activation syndrome, HC hemorrhagic cystitis, ICH intracranial hemorrhage, IFD invasive fungal disease, PGF primary graft failure, PP persistent pancytopenia, SOS synusoidal obstructive syndrome, EMC early mixed chimerism (<day +60), EAR early autologous reconstitution, SGF secondary graft failure