Fig. 1: Time trend of 25-hydroxyvitamin-D3 and 1,25-dihydroxyvitamin-D3 serum levels and association with TRM in the discovery cohort.

Shown are a 25-hydroxyvitamin-D3 (25(OH)D3) or b 1,25-dihydroxyvitamin-D3 (1,25(OH)2D3) serum levels in the discovery cohort that were measured repeatedly at hospital admission (baseline, day −16 to −6), peritransplant (day −2 to 7), during the weekly early follow-up (day 11 to 17, 18 to 24, 25 to 31) and the late follow-up (day 32 to 100 after HSCT) for 143 patients (details see Supplemental Table 1). Also shown is the distribution of c 25(OH)D3 d or 1,25(OH)2D3 levels per time interval separately for patients with or without TRM (23 patients with TRM, 120 patients without). Median serum levels are stated in bold for each boxplot; testing for difference of serum levels between the two groups was performed using Mann–Whitney U test, * or ** indicates a P value ≤0.05 (nominal significance) or ≤0.05/(6 × 2) = 0.004 (Bonferroni-corrected significance level), respectively (see Supplemental Table 1 for details).