Fig. 2: Treatment-related survival and receiver-operating-characteristics curve comparing patients with high versus low peritransplant 1,25-dihydroxyvitamin-D3 serum levels in the discovery cohort.

a Shown is the Kaplan–Meier curve comparing patients above versus below median peritransplant 1,25-dihydroxyvitamin-D3 serum levels (day −2 to 7, median = 172 pM). b Also shown is the Receiver-Operating-Characteristics (ROC) curve for the ability of peritransplant 1,25-dihydroxyvitamin-D3 serum levels to predict TRM. The best cutoff calculated by Youden-Index [15] was derived as 139.5 pM. Embedded in b is the Kaplan–Meier curve using this best cutoff rather than the median in the discovery cohort.