Table 4 Complications in patients with severe CRS.

From: Clinical characterization and risk factors associated with cytokine release syndrome induced by COVID-19 and chimeric antigen receptor T-cell therapy

 

COVID-19 (N = 40)

CAR-T (N = 41)

P value

Respiratory failure, n (%)

38 (95.0%)

9 (22.0%)

<0.001

Acute cardiac injury, n (%)

10 (25.0%)

7 (17.1%)

0.381

Hepatic dysfunction, n (%)

27 (67.5%)

34 (82.9%)

0.107

Acute kidney injury, n (%)

10 (25.0%)

13 (31.7%)

0.503

Secondary infection, n (%)

27 (67.5%)

21 (51.2%)

0.136

Hypoalbuminemia, n (%)

32 (80.0%)

39 (95.1%)

0.048

Transfer to ICU, n (%)

31 (77.5%)

2 (4.8%)

<0.001

Blood transfusion, n (%)

13 (32.5%)

32 (78.0%)

<0.001

Gastrointestinal and craniocerebral hemorrhage, n (%)

3 (7.5%)

3 (7.3%)

1.000

  1. Data were described as n(%). P value were tested by Chi-square test. ICU intensive care unit.
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