Table 5 Treatments in patients with severe CRS.

From: Clinical characterization and risk factors associated with cytokine release syndrome induced by COVID-19 and chimeric antigen receptor T-cell therapy

 

COVID-19 (N = 40)

CAR-T (N = 41)

P value

Oxygen support, n (%)

  

<0.001

No need for oxygen therapy

0 (0)

12 (29.3%)

 

Nasal cannula

0 (0)

15 (36.6%)

 

Non-invasive ventilation or high-flow nasal cannula

25 (62.5%)

12 (29.3%)

 

Invasive mechanical ventilation

4 (10%)

2 (4.9%)

 

Invasive mechanical ventilation and ECMO

11 (27.5%)

0 (0)

 

sCRS treatment, n (%)

  

<0.001

Corticosteroids only

19 (47.5%)

5 (12.2%)

 

Tocilizumab only

0 (0)

20 (48.8%)

 

Corticosteroids and tocilizumab

0 (0)

7 (17.1%)

 

Artificial-liver blood-purification only

1 (2.5%)

0 (0)

 

Corticosteroids and artificial-liver blood-purification

13 (32.5%)

0 (0)

 
  1. Data were described as n(%). P value were tested by Chi-Square test and Fisher’s exact test. ECMO extracorporeal membrane oxygenation.