Table 1 Patient characteristics.

From: Early bilirubinemia after allogeneic stem cell transplantation—an endothelial complication

Cohort

Training, n = 898,

Validation, n = 399,

p

Transplantation period

05/2001–12/2013

01/2013–12/2015

 
 

n (%)

n (%)

 

EB, no SOS/VOD

88 (10)

62 (16)

0.075

EB and SOS/VOD

28 (3)

39 (10)

 

SOS/VOD

43 (5)

44 (11)

 

SOS/VOD no EB (Bili < 3.5)

15 (2)

5 (1)

 

Age (median, range)

54 (17–76)

55 (18–75)

0.081

Statins + UDA (SEP)

501 (56)

0 (0)

<0.001

disease stage high [51]

343 (38)

227 (57)

<0.001

AML

283 (32)

204 (51)

<0.001

ALL

39 (4)

30 (8)

 

MDS

111 (12)

33 (8)

 

MPN

66 (7)

43 (11)

 

Lymphoma

268 (30)

35 (9)

 

MM

130 (14)

37 (9)

 

Others

1 (0)

17 (4)

 

related donor

268 (30)

238 (60)

<0.001

Mismatch <10/10

204 (23)

79 (20)

0.245

ATG

576 (64)

361 (90)

<0.001

  1. EB early bilirubinemia, SOS/VOD sinusoidal obstruction syndrome/veno-occlusive disease, SEP statin-based endothelial prophylaxis, UDA ursodeoxycholic acid, AML acute myeloid leukemia, ALL acute lymphoblastic leukemia, MDS myelodysplastic syndromes, MPN myeloproliferative neoplasms, MM multiple myeloma, RIC reduced intensity conditioning, ATG anti-thymocyte globulin, disease stage (early, intermediate, late).