Table 1 Main biological features during the course of the disease.

CLL

61% CLL lymphocytes (kappa)

2000–2016:

<0.01%

2017: 1%

69% CLL lymphocytes (kappa)

IGHV

IGHV1-3*01

IGHD6-25*01

IGHJ4*02

(100% identity)

FCR3 polyclonal

IGHV1-3*01

IGHD6-19*01

IGHJ4*02 (100% identity)

CLL#1

Cytogenetics

46, XY, del[6](q15)[1]/

46, XY [36]

46,Y, t(X;19)(p11;q13.3)[18]/

46, XY [2]

FISH for 13q, 12, 11q, 17p, IGH, and BCL2 normal

Chimerism

Donor