Table 1 Characteristics of all patients according to HDT.
Patient characteristics | TEAM (n = 35) | Treo/Flu (n = 22) | P-value |
|---|---|---|---|
Median follow-up [days] (range) | 587 (66–2905) | 674 (91–1777) | 0.7729■ |
Median age at HSCT [years] (range) | 54 (23–63) | 65 (49–73) | <0.0001■ |
Median disease stage at HSCT [30] | IV (I–IV) | IV (I–IV) | 0.2654■ |
Gender | 0.2769▼ | ||
Male | 23 (65.7%) | 11 (50.0%) | |
Female | 12 (34.3%) | 11 (50.0%) | |
Disease status at HSCT | |||
CR | 8 (22.9%) | 4 (18.2%) | 0.7496▼ |
PR | 23 (65.7%) | 16 (72.7%) | (CR vs. non-CR) |
PD | 4 (11.4%) | 2 (9.1%) | |
Number of treatment courses before HSCT | |||
Median | 3 | 2 | |
One | 0 (0%) | 0 (0%) | 0.2640■ |
Two | 15 (42.9%) | 13 (59.1%) | |
Three | 16 (45.7%) | 7 (31.8%) | |
Four | 2 (5.7%) | 2 (9.1%) | |
Five | 1 (2.9%) | 0 (0%) | |
Six | 1 (2.9%) | 0 (0%) | |
Disease | |||
DLBCL | 23 (65.7%) | 13 (59.1%) | 0.7786▼ |
FL | 3 (8.6%) | 2 (9.1%) | (HML vs. LML) |
MCL | 9 (25.7%) | 7 (31.8%) | |
IPI at HSCT (number of patients with available IPI) [21,22,23] | 1/27 low ‡ | 1/15 low ‡ | |
2/27 intermediate ‡ | 3/15 intermediate ‡ | ||
2/27 high ‡ | 1/15 high ‡ | ||
1/27 intermediate † | 1/15 intermediate †* | ||
1/27 intermediate †* | |||
1/27 high † | |||
3/27 high †* | |||
6/27 low♦ | 3/15 low-intermediate♦ | ||
5/27 low-intermediate♦ | 3/15 high-intermediate♦ | ||
1/27 low-intermediate♦* | 1/15 high-intermediate♦* | ||
2/27 high-intermediate♦ | 2/15 high♦ | ||
2/27 high♦ | |||
Median HCT-CI (range) [24] | 0 (0–7) | 1 (0–6) | 0.1499■ |
Year of transplantation | |||
2013 | 3 (8.3%) | 0 (0%) | |
2014 | 12 (33.3%) | 0 (0%) | |
2015 | 1 (2.8%) | 0 (0%) | |
2016 | 4 (11.1%) | 4 (18.2%) | |
2017 | 2 (5.6%) | 4 (18.2%) | |
2018 | 3 (8.3%) | 3 (13.6%) | |
2019 | 3 (8.3%) | 4 (18.2%) | |
2020 | 8 (22.2%) | 5 (22.7%) | |
2021 | 0 (0%) | 2 (9.1%) | |
Median number of infused CD34 positive stem cells [x 10E6/kg body weight] (range) | 2.59 (2.01–7.10) | 2.73 (2.04–7.12) | 0.8613■ |
Median number of transfused erythrocyte/thrombocyte concentrates (range) | 5 (0–18)/5 (2-30) | 4 (0–12)/4 (0-11) | 0.1263■/0.0082■ |
Median time of engraftment of leukocytes/thrombocytes [days] (range) | 10 (9–16)/19 (14–83) | 10 (8–16)/18 (10–32) | 0.0197■/0.0979■ |
Median period of hospitalization following reinfusion of stem cells [days] (range) | 20 (13–52) | 17.5 (13–35) | 0.0484■ |