Table 1 Patient and disease characteristics according to donor type.
Characteristics | Total | MSD | MUD | Haplo | P |
|---|---|---|---|---|---|
No. of patients, no. (%) | 242 | 77 (32) | 101 (42)a | 64 (26) | |
Recipient age in years, median (range) | 55 (16–74) | 51 (16–69) | 57 (18–73) | 56 (17–74) | 0.02 |
Sex, no. (%) | 0.4 | ||||
Male | 147 (61) | 50 (65) | 57 (56) | 40 (64) | |
Female | 95 (39) | 27 (35) | 44 (44) | 24 (36) | |
Type of AML, no. (%) | 0.4 | ||||
de novo | 214 (88) | 71 (92) | 87 (86) | 56 (87) | |
tAML/sAML | 28 (12) | 6 (8) | 14 (14) | 8 (13) | |
Disease status at allo-HSCT, no. (%) | 0.4 | ||||
CR1 | 161 (66) | 55 (73) | 69 (68) | 37 (57) | |
≥CR2 | 45 (19) | 11 (14) | 18 (18) | 16 (25) | |
Active disease | 36 (15) | 11 (13) | 14 (14) | 11 (18) | |
ELN 2017 classificationb, no. (%) | 0.045 | ||||
Favorable | 43 (18) | 20 (26) | 10 (11) | 13 (19) | |
Intermediate | 102 (43) | 33 (43) | 40 (41) | 29 (46) | |
Adverse | 95 (39) | 24 (31) | 49 (49) | 22 (35) | |
Disease risk index, no. (%) | 0.8 | ||||
Low | 26 (11) | 11 (14) | 7 (8) | 8 (12) | |
Intermediate | 123 (51) | 40 (52) | 50 (49) | 33 (52) | |
High | 78 (32) | 22 (29) | 37 (36) | 19 (30) | |
Very high | 15 (6) | 4 (5) | 7 (7) | 4 (6) | |
MRD status for patients in CR, no. (%) | 0.15 | ||||
Positive | 63 (26) | 23 (30) | 22 (22) | 18 (28) | |
Negative | 77 (32) | 30 (39) | 29 (29) | 18 (28) | |
Missing | 66 (27) | 13 (17) | 36 (36) | 17 (27) | |
Not applicable | 36 (15) | 10 (14) | 15 (13) | 11 (17) | |
Prior auto-HSCT, no. (%) | 10 (4) | 4 (5) | 3 (3) | 3 (5) | 0.9 |
HCT-CI, no. (%) | 0.6 | ||||
0 | 71 (29) | 20 (26) | 30 (29) | 21 (33) | |
1–2 | 67 (28) | 26 (34) | 27 (27) | 14 (22) | |
≥3 | 104 (43) | 31 (40) | 44 (44) | 29 (45) | |
Median follow-up, months (range) | 25 (6–52) | 24 (7–50) | 19 (6–52) | 23 (7–51) | 0.4 |
