Table 3 Survival (OS, PFS, and GRFS) and cumulative incidences of NRM, RI, and GvHD according to HLA matching at one, two and three years after allo-SCT.

From: Outcome after allogeneic stem cell transplantation with haploidentical versus HLA-matched donors in patients with higher-risk MDS

 

MSD

MUD

HID

At one year

%

95%CI

%

95%CI

%

95%CI

 OS

54.78

[44.56–67.34]

58.88

[51.08–67.87]

35.42

[24.71–51.89]

 PFS

39.97

[30.30–52.74]

50.20

[42.38–59.46]

31.25

[20.54–47.54]

 GRFS

31.91

[22.90–44.48]

35.47

[28.18–44.64]

27.08

[17.03–43.08]

 aGvHD grade 2–4

18.99

[10.28–27.70]

34.31

[26.32–42.29]

37.50

[23.60–51.40]

 cGvHD

29.44

[18.97–39.91]

31.19

[23.22–39.16]

22.92

[10.81–35.03]

 NRM

19.58

[10.59–28.56]

18.57

[11.96–25.19]

33.33

[19.76–46.91]

 RI

40.45

[29.29–51.61]

31.23

[23.33–39.12]

35.42

[21.65–49.18]

At Two years

 OS

34.99

[25.32–48.34]

47.18

[39.24–56.71]

23.77

[14.04–40.22]

 PFS

28.28

[19.34–41.36]

43.10

[35.29–52.64]

20.00

[11.20–35.71]

 GRFS

20.37

[12.69–32.70]

29.48

[22.54–38.55]

15.62

[7.91–30.88]

 cGvHD

31.06

[20.34–41.78]

37.77

[29.33–46.20]

25.00

[12.49–37.51]

 NRM

21.35

[11.88–30.81]

21.98

[14.83–29.12]

33.33

[19.76–46.91]

 RI

50.38

[38.50–62.25]

34.92

[26.65–43.19]

46.67

[31.96–61.37]

At Three years

 OS

26.66

[17.83–39.85]

42.25

[34.32–52.02]

19.80

[10.48–37.42]

 PFS

21.21

[13.21–34.07]

40.12

[32.33–49.78]

20.00

[11.20–35.71]

 GRFS

13.58

[7.31–25.24]

27.51

[20.69–36.58]

15.62

[7.91–30.88]

 cGvHD

32.67

[22.72–43.63]

37.77

[29.33–46.20]

25.00

[12.49–37.51]

 NRM

21.35

[11.88–30.81]

23.99

[16.50–31.47]

33.33

[19.76–46.91]

 RI

57.45

[45.43–69.46]

35.90

[27.53–44.27]

46.67

[21.65–49.18]

  1. GRFS GvHD and relapse free survival, GvHD Graft versus host disease (aGvHD Acute Graft versus host disease, cGvHD Chronic Graft versus host disease), HID Haploidentical donor, MSD Matched sibling donor, MUD Matched unrelated donor, NRM Non relapse mortality, OS Overall survival, PFS Progression free survival, RI Relapse incidence.