Table 4 Median SARS-CoV-2-reactive IgG antibody levels according to the development of breakthrough infection in ASCT and allo-HSCT recipients.

From: SARS-CoV-2-reactive antibody waning, booster effect and breakthrough SARS-CoV-2 infection in hematopoietic stem cell transplant and cell therapy recipients at one year after vaccination

Variables

SARS-CoV-2 infection

No infection

P value

Allo-HSCT

SARS-CoV-2-S-RA at 3-6 weeks (n=315)

45

270

 

 • Median Ab titers in BAU/mL (range)

57 (0–5714)

2191 (0–40000)

0.018

SARS-CoV-2-S-RA at 3 months (n=240)

22

218

 

 • Median Ab titers in BAU/mL (range)

401 (0–5714)

1296 (0–45344)

0.034

SARS-CoV-2-S-RA at 6 months (n=245)

30

215

 

 • Median Ab titers in BAU/mL (range)

202 (0–5714)

1854 (0–95334)

0.001

SARS-CoV-2-S-RA at 12 months (n=191)

7

184

 

 • Median Ab titers in BAU/mL (range)

1590 (0–6423)

3705 (0–26859)

0.13

ASCT

SARS-CoV-2-S-RA at 3-6 weeks (n=101)

21

80

 

 • Median Ab titers in BAU/mL (range)

2500 (0–5700)

1040 (0–41600)

0.2

SARS-CoV-2-S-RA at 3 months (n=70)

10

60

 

 • Median Ab titers in BAU/mL (range)

1279 (0–4602)

469 (0–23700)

0.22

SARS-CoV-2-S-RA at 6 months (n=64)

13

51

 

 • Median Ab titers in BAU/mL (range)

2500 (0–5714)

1844 (0–23426)

0.9

SARS-CoV-2-S-RA at 12 months (n=46)

3

43

 

 • Median Ab titers in BAU/mL (range)

4475 (435–5000)

1820 (0–206568)

0.7

  1. Allo-HSCT refers to allogeneic hematopoietic stem cell transplant, ASCT autologous stem cell transplantation, Ab antibody, SARS-CoV-2-S-RASARS-CoV2-reactive antibodies.