Fig. 1: Examples of positive PET using [18F]GE-180.
From: PET assessment of acute gastrointestinal graft versus host disease
Representative “True Positive” axial images of [18F]GE-180 PET/CT, reproduced with permission from Scott et al. (full details available at https://doi.org/10.1038/s41409-022-01571-3) [66]. Diagnostic imaging was performed at GI-GVHD diagnosis and repeated 7-14 days following treatment commencement, to evaluate correlation with diagnostic histology and clinical response to corticosteroid treatment respectively. Top panel contains study participants’ (1, 4 and 6) “Diagnostic” images, bottom panel contains corresponding “Response” images. Diagnostic [18F]GE-180 PET/CT: increased activity in sigmoid colon (Participant 1), transverse colon (Participant 4) and small bowel (Participant 6), correlating with histological GI-GVHD. Response [18F]GE-180 PET/CT: Complete metabolic resolution of avidity in sigmoid (Participant 1, clinical complete response); partial metabolic resolution in transverse colon (Participant 4, clinical partial response); similar or partial increase in avidity in duodenum (Participant 6, complete response at time of PET with subsequent recurrence of GI-GVHD). [18F]GE-180 PET/CT was performed using a Siemens Biograph mCT Flow 128 Edge 4R PET/CT scanner, and PET SUV window threshold level is set 0-8.
