Table 1 Risk factors for aGVHD.

From: PET assessment of acute gastrointestinal graft versus host disease

Risk factor

Subgroup at increased GVHD risk

Reference

Age

Older recipients

[6, 79]

Donor other than HLA-matched sibling

Matched unrelated, mismatched and/or haploidentical donors

[6, 8, 80, 81]

HPC source

Peripheral blood stem cells

[5]

Conditioning

Myeloablative

[8]

Sex mismatch

Female donor to male recipient

[6]

Donor gravidity

Recipients from multiparous donors

[6, 82,83,84,85]

Intolerance of immune suppression

Early organ failure, e.g. renal/hepatic, necessitating unplanned modifications to GVHD prophylaxis

[86]

GI tract microbiome

Decreased diversity post-HCT associated with increased incidence of GI-GVHD

[74,75,76]

  1. HPC haematopoietic progenitor cells, HLA human leucocyte antigen, GI gastrointestinal.
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