Table 29 Table 1
Patient | Age | Sex | Area of Residency | Hematologic Malignancy | Type of Cellular Therapy | Days to Diagnosis from Cellular Therapy (Days) | Site of Infection | Diagnostic Methodology | Outcome |
|---|---|---|---|---|---|---|---|---|---|
1 | 62 | Male | SCAL* | AML | Allo HCT | 305 | Lungs | Subcarinal lymph node aspiration fungal culture IgG antibody | Deceased due to relapsed AML |
2 | 58 | Male | SCAL | Mantle cell lymphoma | Auto HCT | 503 | Lungs Peritoneum | Ascites fluid fungal culture Antibody CF and IgG | Deceased from advanced cholangiocarcinoma with ESLD |
3 | 63 | Male | SCAL | Hodgkin lymphoma | Auto HCT followed by allo HCT | 28 | Lungs | BAL fungal culture | Deceased within 60 days of transplant due to multiorgan failure |
4 | 54 | Male | CCAL | Peripheral T-cell lymphoma | Allo HCT | 16 | Lungs | BAL cytology | Alive |
5 | 60 | Male | SCAL | Multiple myeloma | Auto HCT | 505 | Lungs | BAL fungal stain and culture Antibody CF, IgG, IgM | Alive |
6 | 25 | Male | SCAL | B-cell ALL | Allo HCT | 84 | Lymph nodes Skin Bone CNS Bone marrow | Axillary lymph node core needle biopsy Chest lesion shave skin biopsy Vertebral body lytic lesion biopsy Bone marrow biopsy Serum antigen Urine antigen | Ongoing antifungal treatment |
7 | 62 | Male | CCAL^ | DLBCL | Yescarta CAR T cell therapy | 174 | Lungs CNS | BAL fungal stain and culture BAL cytology Serum antigen Urine antigen | Deceased due to respiratory failure and persistent infection |
8 | 59 | Fem | CCAL | Myelofibrosis | Allo HCT (haplo) | 150 | Lungs | BAL fungal culture Serum antigen Urine antigen | Alive |
9 | 58 | Fem | SCAL | NHL | Auto HCT | 260 | Lungs | BAL fungal culture Ab IgG and IgM | Deceased due to relapsed NHL |
10 | 17 | Fem | SCAL | ALL | Allo HCT (haplo) | 28 | Lungs | BAL fungal culture BAL cytology Serum antigen Urine antigen KARIUS test | Alive |
11 | 34 | Male | SCAL | T-cell lymphoblastic leukemia | Allo HCT (double cord blood) | 1846 | Lungs Bone CNS | L5 posterior spinous process biopsy CSF Ab IgG Ab CF Serum antigen Urine antigen | Ongoing antifungal treatment |
