Table Multivariable analysis showing hazard ratios of various variables included in the model for various outcomes.

From: The 49th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians - Oral Sessions (O009-O172)

Variables

Modalities

OS

Relapse Incidence

NRM

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

Poor-risk abnormality group

Monosomy 7/del7q or monosomy 5/del5q

1

 

1

 

1

 

11q23 abnormality

0.59 (0.39–0.88)

0.01

0.85 (0.52–1.40)

0.53

0.72 (0.41–1.27)

0.26

Complex or monosomal karyotype

0.94 (0.62–1.42)

0.76

1.00 (0.59–1.71)

0.99

1.00 (0.56–1.80)

1

Other poor risk

0.49 (0.29–0.84)

0.009

0.40 (0.19–0.83)

0.01

0.67 (0.32–1.37)

0.27

Age at HCT

4-12 years

1

 

1

 

1

 

0-4 years

1.16 (0.75–1.79)

0.5

0.73 (0.44–1.22)

0.23

1.48 (0.81–2.71)

0.2

12-18 years

1.71 (1.16–2.52)

0.006

1.04 (0.67–1.63)

0.86

1.95 (1.11–3.40)

0.02

Donor type

Matched related donor

1

 

1

 

1

 

Unrelated donor

0.80 (0.53–1.19)

0.26

0.58 (0.36–0.93)

0.03

0.90 (0.51–1.58)

0.71

Mismatched related donor

0.83 (0.47–1.45)

0.51

0.64 (0.32–1.28)

0.21

1.23 (0.61–2.50)

0.57

Umbilical cord blood

1.19 (0.72–1.97)

0.5

0.91 (0.50–1.69)

0.78

1.28 (0.64–2.59)

0.49

CMV status

Neg to Neg

1

 

1

 

1

 

Neg to Pos

0.87 (0.56–1.36)

0.55

0.95 (0.54–1.68)

0.87

0.91 (0.50–1.66)

0.76

Pos to Neg

1.05 (0.63–1.75)

0.84

1.17 (0.62–2.21)

0.63

0.91 (0.44–1.85)

0.79

Pos to Pos

0.85 (0.57–1.27)

0.43

1.10 (0.67–1.80)

0.71

0.82 (0.48–1.40)

0.47

Diagnosis to HCT (effect for 3-month increment)

0.98 (0.79-1.22)

0.87

0.91 (0.69–1.19)

0.48

1.04 (0.78–1.38)

0.79

Year of HCT (effect for 5-year increment)

0.91 (0.74-1.12)

0.37

0.93 (0.72–1.19)

0.55

0.94 (0.71–1.24)

0.65

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