Table 2 Multivariable Cox PH analysis all patients (n = 89).
From: Predictors of outcomes in hematopoietic cell transplantation for Fanconi anemia
Overall survival | Event-free survival | Treatment-related mortality | ||||
|---|---|---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |
Age at transplant | ||||||
≤8 years | 1 | 1 | 1 | |||
8–18.9 years | 3.1 (0.54–17.6) | 0.20 | 2.1 (0.6–7.3) | 0.25 | 7.5 (0.67–83.4) | 0.10 |
≥19 years | 13.4 (2.3–77) | 0.004* | 8.8 (2.6–30.2) | <0.001* | 29.9 (2.8–319) | 0.005* |
Transplant indication | ||||||
BMF | 1 | 1 | 1 | |||
MDS/AML | 0.51 (0.12–2.1) | 0.35 | 0.36 (0.12–1.1) | 0.08 | 0.21 (0.04–1.2) | 0.072 |
Ex vivo T-cell depletion | ||||||
No | 1 | 1 | 1 | |||
Yes | 1.4 (0.26–7.4) | 0.69 | 2.5 (0.57–10.8) | 0.22 | 1.6 (0.21–11.8) | 0.66 |
Conditioning regimena | ||||||
Including busulfan | 1 | 1 | 1 | |||
Without busulfan | 0.33 (0.05–2.2) | 0.25 | 0.68 (0.15–3.1) | 0.62 | 0.17 (0.01–2.03) | 0.16 |
Including TBI | 0.87 (0.24–3.2) | 0.84 | 0.91 (0.28–3.0) | 0.88 | 0.68 (0.14–3.3) | 0.64 |
HLA match | ||||||
Matched | 1 | 1 | 1 | |||
Mismatched | 4.7 (1.3–16.6) | 0.02* | 6.2 (2.3–16.7) | <0.001* | 10 (1.8–54.2) | 0.008* |
HCT year | ||||||
<2014 | 1 | 1 | 1 | |||
≥2014 | 0.12 (0.02–0.57) | 0.008* | 0.31 (0.11–0.84) | 0.02* | 0.06 (0.01–0.52) | 0.011* |
