Fig. 2: Representative pathology imaging from 3 patients. | Bone Marrow Transplantation

Fig. 2: Representative pathology imaging from 3 patients.

From: Outcomes in hematopoetic cell transplantation in the setting of mold infections in patients with chronic granulomatous disease

Fig. 2: Representative pathology imaging from 3 patients.

a Patient 13, 1 month prior to transplant. Soft tissue with granulation tissue with clusters of multinucleated giant cells and fungal forms present within giant cells (black arrows delineate giant cells, blue arrow shows fungal forms) a1 H&E (left) at 200x, GMS (right) at 400x, a2 H&E (below) at 400x b Patient 16, 3 months prior to transplant. Left upper lobe wedge. Marked granulomatous inflammation with neutrophilic abscess formation. Rare fungal forms are present within the abscess H&E (left) at 100x, GMS (right) at 400x c Patient 22, 3 years prior to gene therapy. Epidural lesion. Fibrous tissue with a dense lymphoplasmacytic infiltrate, multinucleated giant cells and rare fungal forms present. H&E (left), PAS (middle), GMS (right) at 200x.

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