Table 3 Factors associated with overall survival.

From: Influence of pre-transplant estimated glomerular filtration rate (eGFR) on clinical outcomes after allogeneic hematopoietic cell transplantation

 

Univariate

Multivariate

Characteristics

HR (95% CI)

P value

HR (95% CI)

P value

eGFR

 ≥120

1

 

1

 

 90–119

1.46 (0.97,2.20)

0.072

1.26 (0.81,1.95)

0.31

 70–89

1.52 (0.98,2.35)

0.064

1.28 (0.79,2.08)

0.31

 <70

2.28 (1.45,3.56)

<0.001

1.94 (1.17,3.21)

0.01

 <70 vs 70–89

1.50 (1.10, 2.06)

0.01

1.51 (1.09, 2.1)

0.01

 <70 vs 90–119

1.56 (1.19, 2.05)

0.001

1.54 (1.15, 2.07)

0.004

 70–89 vs 90–119

1.04 (0.8, 1.35)

0.77

1.02 (0.78, 1.34)

0.89

Age (years)

 18–59

1

 

1

 

 60–60

1.33 (1.07,1.65)

0.012

1.21 (0.88,1.65)

0.24

 70–79

1.60 (1.13,2.25)

0.008

1.33 (0.87,2.05)

0.19

Gender

 Female

1

   

 Male

1.04 (0.84,1.28)

0.73

  

Race

 Black

1

   

 Caucasian

0.99 (0.61,1.59)

0.96

  

 Other

0.79 (0.37,1.68)

0.54

  

KPS

 90–100

1

 

1

 

 <90

1.59 (1.27,1.99)

<0.001

1.53 (1.20,1.93)

<0.001

Conditioning Intensity

 MAC

1

 

1

 

 RIC

1.40 (1.13,1.73)

0.002

0.93 (0.63,1.36)

0.71

Graft type

 BM

1

 

1

 

 PBSC

1.43 (1.15,1.78)

0.001

1.14 (0.84,1.56)

0.40

Donor source

 Haploidentical

1

 

1

 

 Related donor

0.97 (0.71,1.33)

0.84

0.97 (0.71,1.33)

0.84

 Unrelated donor

1.03 (0.77,1.36)

0.85

1.03 (0.77,1.36)

0.85

Conditioning regimen

 Bu/Flu

1

 

1

 

 Other

1.27 (1.04,1.57)

0.022

0.91 (0.67,1.24)

0.56

PTCy for GvHD prophylaxis

 No

1

   

 Yes

1.07 (0.85,1.34)

0.57

  

HCT-CI without renal

 Low

1

 

1

 

 Intermediate

1.06 (0.76,1.48)

0.75

1.04 (0.74,1.47)

0.83

 High

1.50 (1.10,2.03)

0.009

1.387 (1.02,1.90)

0.04

Donor-Receipt CMV status

 −/−

1

   

 +/+

1.22 (0.91,1.65)

0.19

  

 +/−

1.10 (0.73,1.66)

0.64

  

 −/+

1.09 (0.83,1.45)

0.53

  

DRI

 High

1.60 (1.16,2.20)

0.004

1.45 (1.03,2.04)

0.033

 Intermediate

0.99 (0.73,1.32)

0.92

0.88 (0.65,1.21)

0.44

 Low

--

 

--

 

 NA

0.48 (0.21,1.12)

0.089

0.53 (0.20,1.42)

0.21

Age at HCT, per 10 years

1.18 (1.09,1.28)

<0.001

  
  1. In multivariate analysis, risk of OS in eGFR<70 also remained significantly higher compared to other categories after adjusting for age, KPS, intensity of conditioning, graft type, and Bu/Flu use, HCT-CI without renal function and DRI. Differences among other categories were not significant.
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