Table 3 Distributions between brain and plasma for busulphan and its metabolites.

From: Mechanisms underlying seizures and hypothermia during busulphan administration

Compound

Ratio AUC Brain/AUC Plasma

Bu

1.38

THT

–

THT-1-Oxide

1.07

Sulfolane

1.45

3-OH Sulfolane

0.26

  1. AUC area under the curve, Bu busulphan, THT tetrahydrothiophene.
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