Fig. 1: Proposed algorithm for the management of high-risk and/or relapsed/refractory CTCL.

MF mycosis fungoides, SS Sezary syndrome, allo-HCT allogeneic hematopoietic cell transplantation, CR complete remission, PR partial remission, VGPR very good PR, SD stable disease, PD progressive disease, RIC reduced intensity conditioning. α: patients with SS, rare entities or large cell transformation should be considered to allo-HCT regardless on the line of treatment, in CR or PR; β: according to age, PS, comorbidities; γ: According to center preference; δ: GVHD prophylaxis should follow general guidelines for allo-HCT.