Table 1 Histomorphometry values from L3 vertebrae of wild-type (Lgals3+/+), heterozygous (Lgals3KO/+), and mutant (Lgals3KO/KO) mice at 24 wka

From: Enhanced cortical bone expansion in Lgals3-deficient mice during aging

 

Females

Males

Variables compared

Wild type

Heterozygote

Mutant

Wild type

Heterozygote

Mutant

OV/BV

0.06 ± 0.01

0.06 ± 0.01

0.07 ± 0.01

0.04 ± 0.01

0.05 ± 0.01

0.06 ± 0.01

OS/BS

0.43 ± 0.03

0.47 ± 0.06

0.54 ± 0.02

0.29 ± 0.02

0.30 ± 0.05

0.40 ± 0.05

O.Wi/μm

2.93 ± 0.14

3.08 ± 0.17

3.11 ± 0.13

2.80 ± 0.08

2.91 ± 0.20

2.58 ± 0.12

(N.Ob/BS)/mm-1

48.22 ± 4.52

54.52 ± 9.43

71.66±2.87*

43.61 ± 4.15

40.55 ± 7.82

54.06 ± 5.01

(N.Oc/BS)/mm-1

10.70 ± 1.42

9.20 ± 0.98

9.42 ± 1.93

9.64 ± 1.56

8.04 ± 1.44

8.36 ± 1.85

Oc.S/BS

0.29 ± 0.03

0.26 ± 0.04

0.25 ± 0.04

0.20 ± 0.03

0.17 ± 0.03

0.24 ± 0.04

MS/BS

0.42 ± 0.04

0.46 ± 0.04

0.41 ± 0.06

0.37 ± 0.01

0.36 ± 0.02

0.42 ± 0.02

MS/OS

1.03 ± 0.17

1.00 ± 0.16

0.79 ± 0.09

1.35 ± 0.13

1.47 ± 0.22

1.12 ± 0.12

MAR/(μm·d-1)

1.01 ± 0.07

1.16 ± 0.13

1.06 ± 0.07

0.72 ± 0.03

0.79 ± 0.04

0.77 ± 0.03

Aj.AR/(μm·d-1)

1.06 ± 0.19

1.12 ± 0.16

0.82 ± 0.09

0.98 ± 0.10

1.13 ± 0.13

0.86 ± 0.12

(BFR/BS)/(μm3·μm-2 per day)

0.43 ± 0.05

0.52 ± 0.05

0.42 ± 0.05

0.25 ± 0.02

0.28 ± 0.02

0.32 ± 0.02

(BFR/BV)/% per day

16.61 ± 1.95

19.16 ± 1.57

15.64 ± 2.05

11.28 ± 1.15

12.94 ± 0.54

14.36 ± 1.01

Omt/d

2.97 ± 0.24

2.75 ± 0.29

3.02 ± 0.25

4.01 ± 0.16

3.58 ± 0.25

3.47 ± 0.31

Mlt/d

3.09 ± 0.62

2.91 ± 0.69

2.40 ± 0.35

5.34 ± 0.42

5.21 ± 0.81

3.80 ± 0.37

  1. OV, osteoid volume; BV, bone volume; BS, bone surface; OS, osteoid surface; O.Wi, osteoid width; N.Ob, number of osteoblasts; N.Oc, number of osteoclasts; Oc.S, osteoclast surface; MS, mineralizing surface; MAR, mineral apposition rate; Aj.AR, osteoid adjusted apposition rate; BFR, bone formation rate; Omt, osteoid maturation time; Mlt, mineralization lag time.
  2. aValues are expressed as mean ± S.E.M. (n = 6–9). Holm–Sidak post hoc analysis adjusted P-values compared to wild type; bold values highlight *P < 0.05.