Table 2 Cortical dynamic histomorphometry values of wild-type (Lgals3+/+), heterozygous (Lgals3KO/+), and mutant (Lgals3KO/KO) mice at 24 wka

From: Enhanced cortical bone expansion in Lgals3-deficient mice during aging

 

Females

Males

Variables compared

Wildtype

Heterozygote

Mutant

Wildtype

Heterozygote

Mutant

Ec.MAR/(μm·d-1)

0.69 ± 0.08

0.70 ± 0.06

0.78 ± 0.06

0.66 ± 0.05

0.57 ± 0.05

0.61 ± 0.04

Ec.M.Pm/Ec.Pm

0.65 ± 0.05

0.63 ± 0.05

0.61 ± 0.04

0.70 ± 0.06

0.64 ± 0.05

0.59 ± 0.06

Ec.BFR/(μm2·μm-1 per day)

0.45 ± 0.07

0.45 ± 0.06

0.49 ± 0.06

0.48 ± 0.07

0.37 ± 0.04

0.36 ± 0.04

Ps.MAR/(μm·d-1)

0.61 ± 0.07

0.66 ± 0.04

0.82 ± 0.03*

0.81 ± 0.05

0.75 ± 0.04

0.68 ± 0.06

Ps.M.Pm/Ps.Pm

0.71 ± 0.06

0.73 ± 0.05

0.78 ± 0.05

0.66 ± 0.04

0.63 ± 0.03

0.67 ± 0.05

Ps.BFR/(μm2·μm-1 per day)

0.44 ± 0.06

0.48 ± 0.04

0.64 ± 0.04*

0.54 ± 0.06

0.47 ± 0.03

0.47 ± 0.07

  1. Ec, endocortical; Ps, periosteal; MAR, mineral apposition rate; M.Pm/Pm, mineralizing perimeter/total perimeter; BFR, bone formation rate.
  2. aValues are expressed as mean ± S.E.M. (n = 7–10). Holm–Sidak post-hoc analysis adjusted P-values relative to wild type; bold values highlight *P < 0.05.
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