Fig. 4: Loss of Lrp1 in osteoblasts results in increased osteoclastogenesis in vivo. | Bone Research

Fig. 4: Loss of Lrp1 in osteoblasts results in increased osteoclastogenesis in vivo.

From: Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF–RANKL signaling

Fig. 4

Histomorphometric analysis of lumbar vertebra for a osteoblast number (ObN) per bone perimeter (BPm), b osteoblast surface (ObS) per bone surface (BS), c bone formation rate (BFR), and d BFR assessed by double-calcein labeling. e Osteoclast number (OcN) per BPm and f osteoclast surface (OcS) per BS as well as g urinary bone resorption product deoxypyridinoline (DPD) per creatinine in female Lrp1Runx2Cre mice compared to Lrp1flox/flox controls. Means ± s.e.m., n > 5 per group. (*P < 0.05 as determined by two-tailed, unpaired T-test)

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