Fig. 5: Loss of Lrp1 in osteoblasts results in increased RANKL expression in vivo and in vitro. | Bone Research

Fig. 5: Loss of Lrp1 in osteoblasts results in increased RANKL expression in vivo and in vitro.

From: Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF–RANKL signaling

Fig. 5

a Serum OPG levels. b, c In vivo bone expression of Tnfrsf11b (encoding OPG) quantified by real-time PCR. Nd not detectable. d Serum RANKL levels. e In vivo bone expression of Tnfsf11 (encoding RANKL) and (f) in parts of the femur quantified by real-time PCR. Means ± s.e.m., n = 6 per group. g Tnfrsf11b expression and h Tnfsf11 expression in primary calvarial osteoblasts at days 6 and 21 in differentiation, two independent experiment in triplicates; a–h, *P < 0.05 as determined by two-tailed, unpaired T-test

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