Fig. 6
Ca2+ oscillations in osteocytes govern load-induced bone adaptation by modulating LAMP1 expression. a Representative immunohistochemistry images of LAMP1 and (b) sclerostin staining. Brown cell bodies, positive. c Average difference in percent of osteocytes with positive staining for LAMP1 or (d) sclerostin in vehicle- and neomycin-injected groups sacrificed 30 min or 24 h after the final loading bout. Significant interactions between drug and load in LAMP1 and time and load in sclerostin expression were detected. Within group (#). Between group (*). n = 7 mice /group. P < 0.05. Error bars are standard errors of the mean.
