Fig. 7

Ca2+ oscillations in osteocytes govern load-induced bone adaptation. a Representative µCT scans of trabecular and cortical bone in non-loaded and loaded tibiae from animals injected with neomycin or vehicle control. b Average difference in bone volume fraction (BV/TV) and cortical thickness (Ct.Th) between loaded and non-loaded control limbs in vehicle- and neomycin-injected mice. Significant decreases in loading-related changes were detected in neomycin-injected group. Within group (#). Between group (*). n = 5 mice/group. P < 0.05. Error bars are standard errors of the mean.