Fig. 3
From: Biomimetic delivery of signals for bone tissue engineering
BMP-7-releasing nanofibrous scaffold. a SEM images of BMP-7-encapsulated PLGA nanospheres prepared via double emulsion method. b In vitro BMP-7 release profiles. The release kinetics were modulated by tailoring the chemical and physical properties of the polymer matrix. SEM micrographs of PLGA nanospheres-immobilized on porous NF scaffolds at (c) lower magnification, ×100 and (d) higher magnification, ×10 000. The drug-releasing nanospheres were immobilized onto the internal surface of the scaffold pores. H&E staining of tissue formation in the BMP-7 absorbed scaffold (e) and the BMP-7 controlled releasing scaffold (f) in mouse subcutaneous implantation model, showing that significant bone was regenerated in the BMP-7 controlled release group. Scale bar: 100 µm in (e and f). Copyright © 2006 by Elsevier, reprinted with permission of Elsevier, from Wei et al.38
