Fig. 5
Effect of iguratimod on osteoblast differentiation and bone resorption. a–e Bone destruction detected by histopathology. Osteoclast in a sham (control) group; b vehicle group (number of tartrate-resistant acid phosphatase (TRAP) + cells increased); c low --dose iguratimod group (lesser number of TRAP+ cells); d high-dose iguratimod group (decreased number of TRAP+ cells); e the number of TRAP+ cells in five randomly selected fields at ×400 magnification in each group. f X-ray radiographs of rat tibiae in each group. g The X-ray score in each group. * indicates a significance P-value of less than 0.05. Adapted from Ref., 63 copyright© Sun et al.
