Fig. 7
From: Osteoclast-derived apoptotic bodies couple bone resorption and formation in bone remodeling
Schematic diagram showing the role of osteoclast-derived ABs in bridging bone resorption and formation in bone remodeling. ①A fraction of pOCs undergo apoptosis and secrete pOC-ABs. ② pOC-ABs induce the formation of CD31hiEmcnhi vessels by delivering PDGF-BB to recipient EPCs. ③ pOCs differentiate into mOCs upon stimulation with RANKL and M-CSF. ④ mOCs undergo apoptosis and secrete mOC-ABs at the end of the bone resorption phase. ⑤ mOC-ABs promote osteogenesis through RANKL reverse signaling. In addition, CD31hiEmcnhi vessels induced by pOC-ABs improve local nutrient and metabolic waste transport to further maintain the integrity of bone remodeling
