Fig. 7
From: Nrf2 epigenetic derepression induced by running exercise protects against osteoporosis
A schematic diagram of mouse running exercise, Nrf2 promoter demethylation and protection against osteoporosis (OP). Ovariectomized mice display increased femoral Dnmt1/3a/3b (Dnmts), Nrf2 promoter hypermethylation and Nrf2 suppression, which promote oxidative stress (OS), osteoclastogenesis (OCG) and OP (dashed line). Running exercise (RE, solid line) normalizes Dnmt aberrations, resulting in Nrf2 promoter demethylation, Nrf2 recovery and reduced femoral osteoporotic pathologies
