Fig. 1 | Bone Research

Fig. 1

From: Targeted Ptpn11 deletion in mice reveals the essential role of SHP2 in osteoblast differentiation and skeletal homeostasis

Fig. 1

Mice lacking SHP2 in Bglap+ osteoblasts and osteocytes display skeletal dysplasia, reduced BMD, and the growth of enchondromas and osteochondromas. a Radiographs of 13-week-old SHP2CTRBglap and SHP2KOBglap mice showing the skeletal structure, femur length (lines), and BMD (arrows). X-ray (b) and µCT (c) radiographs of skeletal preps from the mice described in a. Note the reduced BMD, deformed knee and hip joints, and growth of osteochondromas in SHP2KOBglap mice (arrows) (n = 5)

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