Table 1 H &E and TRAP stained bone sections were used for analyses in BioQuant-Osteoimage analysis software

From: Peptidomimetic inhibitor of L-plastin reduces osteoclastic bone resorption in aging female mice

Parameters

36 + 14 weeks scrambled

36 + weeks inhibitory

Static

Cancellous bone/%

10.65 ± 3.3

14.36 ± 2.86

Trabecular number/mm−1

1.06 ± 0.23

2.25 ± 0.46*

Trabecular thickness/µm

7.8 ± 1.6

12.43 ± 2.3**

Trabecular separation/µm

420.8 ± 35.92

302.6 ± 15.9**

Osteoclast number

29.93 ± 10.87

25.5 ± 8.58

Osteoblast number

179 ± 35.47

214 ± 42.81

Cortical width/µm

158 ± 7.3

165.8 ± 6.83

Dynamic

MAR/(μm·d−1)

0.38 ± 0.05

0.42 ± 0.09

Bone formation rate/(μm2·μm−1 per day)

0.30 ± 0.08

0.29 ± 0.03

  1. Data shown are mean ± SEM of nine mice from one experiment (n = 9 per group)
  2. *P < 0.05 and **P < 0.01 vs. scrambled peptide injected mice. The standard Student’s t test was used to assess P values. The results represent one of the three experiments performed
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