Fig. 5 | Bone Research

Fig. 5

From: Skeletal loading regulates breast cancer-associated osteolysis in a loading intensity-dependent fashion

Fig. 5

Tibia loading setup and strain measurement. a C57BL/6 mouse on a tibia loading device. b, c Strain measurement using a pair of strain gauges. d Representative dynamic measurement of displacement and strain using a digital image correlation (DIC) method. e DIC-based strain measurement of the proximal tibia in response to 1, 2, and 5 N loads to the tibia. The negative strain value is compressive in response to tibia loading. f Section of the proximal tibia (2 mm in length) analyzed by μCT. g, h Loading magnitude-dependent alterations in trabecular bone in the proximal tibia by tibia loading (1 N and 5 N) in BALB/c control mice without tumor inoculation (N = 6 per group)

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