Fig. 6 | Bone Research

Fig. 6

From: An enhanced chemopreventive effect of methyl donor S-adenosylmethionine in combination with 25-hydroxyvitamin D in blocking mammary tumor growth and metastasis

Fig. 6

Comparison of DEGs in response to SAM + 25(OH)D with the DEGs in murine bone metastasis dataset. a Venn diagram of the up- and downregulated genes following combination treatment with SAM + 25(OH)D that overlapped with differentially expressed genes in a murine model of breast cancer bone metastasis in GSE37975. Here, BM: Bone metastasis b Molecular interaction networks of the encoded proteins from the 27 uniquely upregulated genes in the combination treatment are determined by the STRING database. c Summary of the anticancer effects mediated by SAM + 25(OH)D in vitro and in vivo. The combination treatment causes a significant reduction in cell proliferation and colony formation in a battery of breast cancer cell lines in vitro and reduces primary mammary tumor volume, visceral, and skeletal colonization by breast tumor cells in vivo. These anticancer effects were mediated through the differential regulation of key cancer and immune-related pathways, as shown by the transcriptome analyses

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