Fig. 1
From: Sympathetic activity in breast cancer and metastasis: partners in crime

Sympathetic control of breast cancer progression. NE released from sympathetic neurons closely associated with blood vessels, as well as Epi that diffuses from the circulation, modulate several important hallmarks of breast cancer such as survival, angiogenesis, immune surveillance escape, ECM remodeling and invasion. NE, norepinephrine; Epi, epinephrine; TAM, tumor-associated macrophage; ECM, extracellular matrix