Fig. 4
From: Sympathetic activity in breast cancer and metastasis: partners in crime
Breast cancer cell extravasation into the bone niche. NE stimulation of stromal β2-AR is associated with an increased release of VEGF and IL-1β, which leads to augmented angiogenesis and expression of P- and E-selectins in endothelial cells. The latter event promotes breast cancer cell extravasation from the circulation into the bone marrow
