Fig. 5
From: Endocrine role of bone in the regulation of energy metabolism
The network relationship between bone and whole-body energy metabolism. Aging is one of the main causes of bone and whole-body metabolism disorder, and exercise training can alleviate it. Changes in bone metabolism will affect multiple organs and tissues, including the brain (a potential research direction in the future), and lead to metabolic diseases. Metabolic diseases, as well as changes in circulating endocrine factors, can in turn affect bone. On the other hand, bone-derived factors can also be used as autocrine factors to regulate their own metabolic state
