Table 1 Chondrocytes were treated with IL-1β for 24 h. RNA sequencing was performed and significantly altered pathways are displayed
From: IκB-ζ signaling promotes chondrocyte inflammatory phenotype, senescence, and erosive joint pathology
Pathway | P-value |
|---|---|
Regulation of cell proliferation | 1.55E-13 |
Cellular response to DNA damage stimulus | 1.23E-12 |
Positive regulation of apoptotic process | 2.63E-10 |
Apoptotic process | 8.49E-09 |
Intrinsic apoptotic signaling pathway in response to DNA damage | 1.17E-06 |
Regulation of apoptotic process | 3.66E-06 |
Intrinsic apoptotic signaling pathway in response to oxidative stress | 8.66E-05 |
Extrinsic apoptotic signaling pathway | 2.46E-04 |
Positive regulation of cell death | 1.63E-03 |
Positive regulation of cell cycle arrest | 3.54E-03 |
Apoptotic mitochondrial changes | 8.60E-03 |
Cellular senescence | 1.49E-02 |
Replicative senescence | 3.90E-02 |
