Fig. 1 | Bone Research

Fig. 1

From: Restoring the dampened expression of the core clock molecule BMAL1 protects against compression-induced intervertebral disc degeneration

Fig. 1

BMAL1 shows a negative correlation with the degree of IDD. a Immunofluorescence of BMAL1 in 8 pairs of human NP samples with different IDD severities from each patient. Scale bar: 50 μm. Green triangles: IVDs with moderate IDD severity; red triangles: IVDs with severe IDD severity. n = 8. b Quantification of the percentage of BMAL1-positive cells in 8 pairs of human NP samples with different IDD severities from each patient. Paired Student’s t test. c Single-factor linear regression analysis of the relationship between the percentage of BMAL1-positive cells and Pfirrmann grades based on 149 NP samples. d Multivariate linear regression analysis of the relationship between all variables (Pfirrmann grades and ages) and the percentage of BMAL1-positive cells. e Logistic regression analyses for the relationship between all variables (BMAL1 positive rate, sex and age) and IDD severity. f Single-factor linear regression analysis of the relationship between the percentage of BMAL1-positive cells and age for NP tissues of similar Pfirrmann grades. **P < 0.01

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