Fig. 4 | Bone Research

Fig. 4

From: Restoring the dampened expression of the core clock molecule BMAL1 protects against compression-induced intervertebral disc degeneration

Fig. 4The alternative text for this image may have been generated using AI.

Deletion of Bmal1 leads to the degradation of ECM in NP tissue. a Representative µCT scans of the lumbar spine of a WT mouse and a KO littermate (6 months). White triangles: lumbar IVDs. n = 4. b Representative MRI scan of the mouse lumbar spine. White triangles: lumbar IVDs. n = 3. c Quantification of the relative signal intensity of MRI and DHI% of µCT. Student’s t test. d HE and SO staining of the IVDs from the lumbar spine of a WT mouse and a KO littermate (6 months). Scale bar: 100 μm. e Representative images of immunofluorescence of BMAL1, Aggrecan and MMP13. White arrows: NP tissues; green arrows: inner AF tissues. Scale bar: 100 μm. The data in the figures represent the mean ± S.D. **P < 0.01, *P < 0.05

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