Fig. 7 | Bone Research

Fig. 7

From: Restoring the dampened expression of the core clock molecule BMAL1 protects against compression-induced intervertebral disc degeneration

Fig. 7

Proposed schematic representation for this study. a Clinical sample collection and analysis of BMAL1 levels. b Molecular mechanism of excessive loading dampening the circadian clock of IVDs and upregulating BMAL1 expression by RhoA/ROCK pathway inhibition to attenuate compression-induced IDD. c Melatonin and Y-27632 partially restored BMAL1 expression and alleviated IDD in a diurnal compression model

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