Fig. 9 | Bone Research

Fig. 9

From: mTORC1 induces plasma membrane depolarization and promotes preosteoblast senescence by regulating the sodium channel Scn1a

Fig. 9The alternative text for this image may have been generated using AI.

Model of the sodium channel Scn1a in regulating preosteoblast senescence. Scn1a expression is positively regulated by mTORC1 upstream of C/EBPα, whereas its permeability to Na+ is gated by protein kinase A (PKA)-induced phosphorylation. Prosenescent stresses increase the permeability of Scn1a to Na+ by suppressing PKA activity and induce depolarization in preosteoblasts. Depolarization increases Ca2+ influx and activates downstream NFAT/ATF3/p53 signaling, thus promoting preosteoblast senescence

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