Fig. 6 | Bone Research

Fig. 6

From: Systemic IL-27 administration prevents abscess formation and osteolysis via local neutrophil recruitment and activation

Fig. 6

The effects of IL-27 on implant-associated osteomyelitis depend on IL-27Rα expression. Female IL-27Rα−/− mice (n = 5) were injected with rAAV-IL-27p28 or rAAV-GFP and challenged with a MRSA-contaminated transtibial implant as described in Fig. 3. Animal weights (a) and BLI values (b) were measured on Days 0, 1, 3, 7, 10 and 14, and the data are presented as the mean ± SD for the group (n = 5). c Representative photographs acquired on Day 14 post-surgery show similar large draining abscesses in both groups. d CFUs in the implant, surgical site soft tissue, and tibia were quantified after euthanasia on Day 14 post-surgery, and the data for each tibia are presented with the mean ± SD for the group (n = 5). e Peri-implant osteolysis on Day 14 was evaluated by μCT analyses (n = 3). No differences were observed between the experimental groups

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