Fig. 7 | Bone Research

Fig. 7

From: Systemic IL-27 administration prevents abscess formation and osteolysis via local neutrophil recruitment and activation

Fig. 7

Schematic model of IL-27-mediated immune regulation during S. aureus osteomyelitis. a S. aureus induces IL-27 expression via TLR activation in osteoblasts and macrophages early during the onset of osteomyelitis. Secretion of IL-27 is dependent on the autoregulatory IL-27 signaling pathway. However, endogenous IL-27 does not influence host susceptibility to osteomyelitis. b On the other hand, expression of IL-27 due to administration of rAAV-IL-27p28 at supraphysiologic levels induces the accumulation of proinflammatory IL-17-producing RORγt+ neutrophils, leading to decreased abscess formation and increased bacterial clearance at the site of infection. Furthermore, the abundance of IL-27 suppresses RANK expression and inhibits osteoclast differentiation, leading to decreased bone osteolysis during chronic osteomyelitis

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